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The Release Notes are provided as a reference tool and are not intended 3. Using the Specifications Manual for National Hospital Inpatient Quality Measures.

The present application relates to the field of singledomain antibodies (also called nanobodies), more particularly singledomain antibodies against SOD1 protein isoforms. It also relates to the use of these nanobodies in medicine. Accordingly, methods to treat a disease using these nanobodies are provided herein. The singledomain antibodies are particularly envisaged for treatment of ALS.